Development of Zero-Emission Asymmetric Synthesis System Based on Complete Recovery and Reuse of Chiral Catalyst and Reaction Solvent

为了将手性催化剂-离子液体反应体系发展为零排放的不对称反应体系，使其反应溶剂和手性催化剂可以完全同时回收和重复使用，本发明成功合成了新型双离子手性稀土金属配合物，其对离子液体具有高亲和性，并可作为离子液体中不对称选择性Diels-Alder反应的有效刘易斯酸催化剂。反应结束后，用有机溶剂萃取产物和未反应的底物时，催化剂完全保留在离子液体中，含有催化剂的离子液体可以成功地重复用于下一步反应。同时，对不对称催化与催化剂或离子液体结构活性相关性的研究为开发新型高功能催化剂提供了新的思路。

In order to develop a chiral catalyst-ionic liquid reaction system as an zero-emission asymmetric reaction system, both a reaction solvent and a chiral catalyst of which can be completely and simultaneously recovered and reused, novel diionic chiral rare earth metal complexes were succeeded in synthesizing, which had a high affinity for ionic liquids, and could work as an effective Lewis acid catalyst for the enantioselective Diels-Alder reaction in an ionic liquid. After the reaction, the catalysts completely remained in the ionic liquid in extracting the products and the unreacted substrates with organic solvent, and the ionic liquid involving the catalyst could be successfully reused for the next reaction. Also, investigations about structure activity correlation between asymmetric catalysis and catalysts or ionic liquids used provided new insights to develop new highly functional catalysts.