Intracellular dynamics of traction forces under physiological mechanical stimulations

对我们身体产生的机械压力会导致多种疾病。在这项研究中，为了了解机械应力是如何参与这些疾病的，我们试图测量细胞内牵引力的变化。针对测量问题，研制了测量系统。此外，作为这种改变的一种机制，细胞骨架被认为是一个力学模型。因此，尽管细胞内牵引力的变化仍然是有效分析不可或缺的噪声，但细胞牵引力的变化也是有效的。此外，随着细胞骨架的改变，研究表明，细胞骨架的消融导致了细胞牵引力的几种类型的改变。

Mechanical stresses induced on our body involve in multiple disorders. In this study, in order to understand how the mechanical stresses involve in those disorders, intracellular alterations of traction force were tried to be measured. For the measurement, measuring system was developed. Moreover, as a mechanism of the alterations, cytoskeletons were considered as a mechanical model. As a result, although alterations of intracellular traction forces remain indispensable noises for valid analysis, those of cellular traction forces were valid. In addition with alterations of cytoskeletons, it was indicated that ablation of cytoskeletons induced several types of alterations in cellular traction forces.