Search for anti-aging compounds from medicinal flowers

我们从药用花卉中研究了抗衰老化合物。结果发现，茶花、荷叶莲子、梅子、加南加和黑茉莉花蕾或花中的几种成分及其衍生物（齐齐烷型三萜皂苷、苯基异喹啉生物碱、酰化奎宁酸、木脂素和类黄酮）对茶碱刺激的B16黑色素瘤4A5细胞的黑色素生成有抑制作用。进一步研究了相关化合物对黑素形成的抑制作用，并对其构效关系进行了表征。此外，本文还部分阐明了金银花花蕾中主要化合物——金银花素对黑色素形成的作用机制。

We have researched anti-aging compounds from medicinal flowers. As the results, several constituents and its derivatives (oleanane-type triterpene saponins, benzylisoquinoline alkaloids, acylated quinic acids, lignans, and flavonoids) from the flower buds or/and flowers of Camellia japonica, Nelumbo nucifera, Prunus mume, Cananga odorata, and Lawsonia inermis were found to show inhibitory effects on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells. Furthermore, the inhibitory effects of the related compounds on melanogenesis were examined and their structure-activity relationships were characterized. In addition, we clarified a part of the mechanism of actions of nuciferin, which was the main compound of the flower buds of N. nucifera, on melanogenesis.