the effect of HCV-Core protein on histone-modification system of host cell

丙型肝炎病毒（HCV）感染影响3%的人口，或全球约1.7亿人，并且它导致严重的肝脏疾病，如肝癌、肝细胞癌（HCC）。近年来，针对HCV的高效药物已经被开发出来。然而，在病毒排除后，致癌的风险仍然很高。重要的是要了解在HCV感染的致癌作用早期发生了什么。在本研究中，我专注于HCV-Core蛋白对基因表达调控的作用。核心蛋白被认为是HCV致癌的重要蛋白质。结果表明，预期Core蛋白的表达通过协调基因表达的组蛋白的重排修饰而进入癌变过程。

Infection with hepatitis C virus (HCV) affects 3% of the human population, or roughly 170 million individuals worldwide, and it leads to severe liver disorders,such as liver cancer, hepatocellular carcinoma (HCC). Recently, high efficient drugs against HCV have been developed. However, the risk of carcinogenesis is still high after the virus exclusion. It is important to understand what is taking place early in carcinogenesis by the HCV infection. In this study, I focused on the effect of HCV-Core protein on regulation of gene expression. The Core protein was known as important protein for HCV-oncogenesis. As a result, it followed that it was expected that the expression of Core protein went to the carcinogenesis by rearranging modification of the histone protein which coordinated gene expression.