Comprehensive analysis of genetic abnormalities in gastrointestinal cancers and the identification of molecular targeted therapy targeting those alterations

由于许多国家的人口老龄化，老年结直肠癌（CRC）患者的数量预计将增加。美国和欧洲国家的既往研究表明，老年CRC患者的临床和分子特征是女性、右侧结肠、BRAF突变、MLH 1甲基化和微卫星不稳定性（MSI），这些CRC的前驱病变似乎是锯齿状病变。日本的人口老龄化速度比任何其他国家都快;然而，尚未对日本老年患者的大量人群中的CRC和锯齿状病变的特征进行研究。因此，我们进行了一项回顾性的大规模日本队列研究，并检查了老年患者的临床病理学和分子特征。

The number of elderly colorectal cancer (CRC) patients is expected to increase because of the aging populations in many countries. Previous studies in the U.S. and European countries have shown that the clinical and molecular features of elderly CRC patients were female, right-side colon, BRAF mutation, MLH1 methylation and microsatellite instability (MSI) and that the precursor lesions of those CRCs appeared to be serrated lesions. With regard to Japan, the population is aging much faster than that of any other countries; however, there has been no study on the characteristics of CRCs and serrated lesions in a large population of elderly Japanese patients. We therefore conducted a retrospective large-scale Japanese cohort study and examined the clinicopathological and molecular features of elderly patients.