Development of observational tool of the vascular lumen vessel wall of pulmonary artery lesion in patients with pulmonary hypertension.

(1)慢性血栓栓塞性肺动脉高压(CTEPH)患者肺血管病变的OCT图像呈网络状，经皮腔内肺血管成形术(PTPA)可明显改善患者的症状、BNP水平、肺血流动力学。PTPA组的预后也明显好于历史组(P&lt；0.05)。(2)在肺动脉高压动物模型中，我们检测了小的肺动脉和肺动脉主干的病变，以及右室(RV)功能。肺动脉高压早期RV重构通过纤维化、血管周围重构、毛细血管疏松和自噬等途径发生，eNOS途径和胶原代谢可能参与其中。

(1) OCT images of the pulmonary artery lesion in patients with pulmonary hypertension showed network-shaped web image in patients with chronic thromboembolic pulmonary hypertension (CTEPH).Percutaneous transluminal pulmonary angioplasty (PTPA) significantly improved symptom, BNP levels, pulmonary hemodynamics. Also, PTPA group had significantly better prognosis compared with historical group (P<0.05).(2) In pulmonary hypertension animal models, we examined the small pulmonary artery and pulmonary artery main trunk lesions, and the right ventricular (RV) function. RV remodeling occurs early in PH development through fibrosis, perivascular remodeling, capillary rarefaction and autophagy, for which eNOS pathway and collagen metabolism may be involved.