Molecular mechanism of anti-inflammatory properties of parasympathetic nervous system and its application in pharmacotherapy of abdominal aortic aneurysm

在本研究中，我们研究了乙酰胆碱酯酶抑制剂多奈哌齐对内毒素诱导的巨噬细胞炎症的影响。结果表明，多奈哌齐通过减轻内毒素诱导的核转位，减少促炎细胞因子的表达和分泌。乙酰胆碱或其他乙酰胆碱酯酶抑制剂均不能复制多奈哌齐的抗炎作用，表明多奈哌齐通过一种独立于其抑制乙酰胆碱酯酶的药理性质的机制直接影响细胞。

In the present study, we investigated the effect of donepezil, an acetylcholinesterase inhibitor, on the endotoxin-induced inflammation in macrophage cells. As results, donepezil reduced the expression and secretion of pro-inflammatory cytokines by attenuating the LPS-induced nuclear translocation of NF-kB. Neither acetylcholine nor other acetylcholinesterase inhibitors reproduced the anti-inflammatory action of donepezil, indicating that donepezil directly affects cells via a mechanism which is independent of its pharmacological property of acetylcholinesterase inhibition.