A role of Fc receptor beta-chain in the onset of arthritis elicited by anti-type II collagen antibodies

Fc受体β链（FcRβ）作为免疫细胞（如肥大细胞（MC）或嗜碱性粒细胞）中FcγRIII的信号传导组分。最近的研究报告，FcγRIII有助于关节炎炎症的发展。提示FcRβ可能在关节炎的发病机制中起重要作用。为了解决这种可能性，我们采用小鼠模型检测了FcRβ在关节炎炎症中的功能。我们的研究结果表明，在实验模型中，FcRβ负性调节Fc γ RIII介导的MC活化和关节炎炎症。

Fc receptor β chain (FcRβ) acts as a signaling component of FcγRIII in immune cells such as mast cells (MCs) or basophils. Recent studies reported that FcγRIII contributes to the development of arthritic inflammation. These findings suggest that FcRβ may play pivotal role in the pathogenesis of arthritic inflammation. To address this possibility, we examined the function of FcRβ in arthritic inflammation employing a mouse model. Our findings indicate that the FcRβ negatively regulatesFcγRIII-mediated MC activation and arthritic inflammation in experimental model.