Genetic analysis of patent ductus arteriosus in preterm infants.

动脉导管未闭是一种与早产相关的常见疾病。我们的主要目的是确定遗传风险因素是否在早产儿动脉导管患者中起作用。从80个胎龄小于32周的婴儿中收集DNA样本。41名男生和39名女生。平均胎龄29周（22 ~ 31周），平均出生体重1059g （476 ~ 2158g）。30%的婴儿动脉导管自然闭合，46%的婴儿使用一次吲哚美辛，23%的婴儿使用两次吲哚美辛。7%的婴儿进行了动脉导管的手术闭合。采用实时聚合酶链反应研究了转录因子AP-2的单核苷酸多态性。

Patent ductus arteriosus is a common morbidity associated with preterm birth. Our major goal was to determine if genetic risk factors play a role in patient ductus arteriosus seen in preterm infants. DNA samples collected from 80 infants with a gestational age less than 32 weeks. There were 41 boys and 39 girls. Mean gestational age was 29 weeks (22-31 weeks), mean birth weight was 1059g (476-2158g). Natural close of ductus arteriosus was seen in 30% in infants, indomethacin with one time was used in 46% in infants, and indomethacin with two times were used in 23% in infants. Surgical closure of ductus arteriosus was proceeded in 7% in infants. We investigated single nucleotide polymorphism in transcription factor AP-2 by real time polymerase chain reaction.