Establishment in evaluating antitumor immunity of inactivated HVJ-Eto malignant melanoma

我们评估了灭活HVJ-E在晚期恶性黑色素瘤患者体内诱导的体液免疫和细胞免疫。结果，我们检测到一种新的特异性自身抗体，该抗体在人类和黑色素瘤细胞小鼠中随着HVJ-E的施用而上调。CD4^+/ CD8^+T细胞和CD11c^+树突状细胞强烈浸润，特别是浸润到萎缩的黑色素瘤组织中，提示HVJ-E可增强恶性黑色素瘤的综合抗肿瘤免疫。

We evaluated the inducible humoral and cellular immunity of inactivated HVJ-E in the patients with advanced malignant melanoma. As results, we detected a novel and specific auto-antibody which was upregulated with HVJ-E administration in human as well as in melanoma cells bearing mice. CD4^+/ CD8^+T cells and CD11c^+dendritic cells robustly infiltrated particularly into the shrinking melanoma tissues, indicating that HVJ-E could augment the comprehensive anti-tumor immunity in malignant melanoma.