Role of ubiquitin-preteasome system in the immune-complex disease

为了评估泛素-前蛋白酶体系统在免疫复合物疾病中的作用，在用或不用硼替佐米抑制蛋白酶体的野生型小鼠中检查皮肤Arthus反应。与未治疗的小鼠相比，硼替佐米治疗的野生型小鼠中由免疫复合物激发诱导的水肿和出血显著减少。与未治疗小鼠相比，硼替佐米治疗的野生型小鼠在Arthus反应期间皮肤白细胞介素-6、肿瘤坏死因子-a和诱导型一氧化氮合酶的产生增加受到抑制，这表明皮肤炎症减少。这些结果表明硼替佐米治疗可能是治疗免疫复合物疾病的一种有前途的策略。

To assess the role of ubiquitin-preteasome system in the immune-complex diseases, the cutaneous Arthus reaction was examined in wild type mice with or without proteasome inhibition by bortezomib. Edema and hemorrhage induced by immune complex challenge significantly decreased in bortezomib-treated wild type mice compared with untreated mice. Increased cutaneous production of interleukin-6, tumor necrosis factor-a and inducible nitric oxide synthase during Arthus reaction was inhibited in bortezomib-treated wild type mice relative to untreated mice, which paralleled the reduction in cutaneous inflammation. These results suggest that bortezomib treatment could be a promising strategy for treating immune-complex diseases.