High Energy Materials for Cancer Drugs: A Novel Mechanism of Action

设计并合成了一种新型抗癌药物三氟乙氧基酞菁-氨基四唑偶联物（TFEO-Pc-AT）。利用铜催化的1-（2-叠氮乙基）-5-氨基四唑与含末端炔的酞菁的Click反应，很好地合成了目标化合物。TFEO-Pc-AT在660 nm激光照射下对B16-F10小鼠黑色素瘤显示出优异的光动力学活性，而在没有照射的情况下没有观察到TFEO-Pc-AT的细胞毒性。

Designed and synthesis of a novel anti-cancer agent, trifluoroethoxyphthalocyanine-aminotetrazole conjugate (TFEO-Pc-AT) is described. The target compound was synthesized nicely by the use of copper-catalyzed Click-reaction of 1-(2-azidoethyl)-5-aminotetrazole and phthalocyanine containing terminal alkyne as a key step. TFEO-Pc-AT showed excellent photodynamic activities against B16-F10 murine melanoma upon illumination with a 660 nm laser, while no cytotoxicity of TFEO-Pc-AT was observed without illumination.