Development of a novel transcutaneous vaccination device using a dissolving microneedle array.

与常用的注射系统相比，经皮免疫（TCI）是一种有吸引力的替代接种途径。我们开发了一种溶解微针阵列，用作TCI装置，并报告了具有溶解微针阵列的TCI诱导针对模型抗原的免疫应答。在本研究中，我调查了使用该疫苗接种系统的流感疫苗接种效果。在流感HA疫苗接种时，在小鼠中引发了稳健的抗体产生，其提供了针对随后的流感病毒攻击的完全保护。这些发现表明，使用溶解微针阵列的TCI可以引发针对感染性疾病的大的免疫应答。基于这些结果，我们现在正在为人类临床试验准备转化研究。

Transcutaneous immunization (TCI) is an attractive alternative vaccination route compared to the commonly used injection systems. We developed a dissolving microneedle array for use as a TCI device, and reported that TCI with the dissolving microneedle array induced an immune response against model antigens. In this study, I investigated the vaccination efficacy against influenza using this vaccination system. On influenza HA vaccination, robust antibody production was elicited in mice that provided complete protection against a subsequent influenza virus challenge. These findings demonstrate that TCI using a dissolving microneedle array can elicit large immune responses against infectious diseases. Based on these results, we are now preparing translational research for human clinical trials.