Quality control of genomes of RNA viruses

关于RNA病毒基因组的质量控制知之甚少，例如为了防止无功能的病毒RNA在细胞中的积累。作为探讨病毒生命周期中RNA质量控制降解可能的分子机制的第一步，我们寻找了与丙型肝炎病毒RNA基因组非翻译区（UTR）结合的宿主细胞蛋白，并鉴定了PSF、hnRNP-H和p54-nrb为5 'UTR III d结合因子。hnRNP-H可能通过与病毒核衣壳蛋白相互作用参与病毒RNA的稳定性。

Little is known about quality control of genomes of RNA viruses such as in order to prevent accumulation of nonfunctional viral RNAs in cells. As a first approach to address possible molecular mechanism(s) involved in quality control degradation of viral RNA in virus lifecycles, we searched host cellular proteins that bind the untranslated regions (UTR) of hepatitis C virus RNA genome, and identified PSF, hnRNP-H and p54-nrb as 5’UTR IIId-binding factors. It may be likely that hnRNP-H is involved in the viral RNA stability via its interacting with the viral nucleocapsid protein.