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A novel study elucidating risk of particulate matters using iPS

A novel study elucidating risk of particulate matters using iPS
一项利用 iPS 阐明颗粒物风险的新研究
批准号:
23659337
负责人:
INOUE Ken-ichiro
金额:
$2.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
翻译
首先,我们研究了iPS分化为心肌细胞(如心肌细胞和血管内皮细胞)的体外实验条件,并开发了分化iPS来源的心肌细胞的条件。接下来,我们研究了柴油废气颗粒(DEP)暴露对ips来源的肌细胞的体外影响,发现与车辆暴露相比,DEP倾向于抑制这些细胞的脉动。
英文摘要
At first, we examined in vitro assay conditions differentiating iPS toward cardiac cells such as myocytes and vascular endothelial cells , and developed condition differentiating iPS-derived myocytes. Next, we investigated the in vitro effects of diesel exhaust particle (DEP) -exposure on iPS-derived myocytes, and found that DEP tended to suppress pulsation of these cells as compared to vehicle-exposure.
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