Development of image diagnosis and treatment for fluminant myocarditis

自身免疫性心肌炎所致的荧光性心肌炎预后较差。因此，开发治疗荧光性心肌炎的新方法是医学上尚未满足的需求。我们发现，心肌炎心脏中有纳米颗粒的积聚。然后，我们研制了包被纳米脂质体的FK506(一种免疫抑制药物)。在大鼠心肌炎模型上，我们发现脂质体FK506比FK506更能预防心功能不全。脂质体有望成为治疗迁延性心肌炎的新方法。

The prognosis of fluminant myocarditis due to autoimmune myocarditis is poor. Thus, the development of new treatment for fluminant myocarditis is medical unmet need. We found that nano-size particles were accumulated in myocarditis hearts. Then, we have developed FK506(an immunosuppressant drug) coated with nano-size liposome. In rat myocarditis model, we found that liposomal FK506 prevented the cardiac dysfunction more than FK506 did. Liposomes are promising for developing new treatments for fluminant myocarditis.