Search study of the enuresis genes by inhabitants examination cohort

遗尿症被认为与遗传背景有关，但尚未对相关基因进行研究。然后，我们旨在通过参考一般人群的遗尿史来阐明责任基因。但遗传学分析明显滞后，因此我们建立了反映遗尿生理机制的动物实验模型，旨在以此途径探讨遗尿的相关基因。结果，我们发现候选基因“PTHrP”是一种有效的内源性膀胱收缩松弛剂。

Enuresis is considered to be related to genetic background, but no responsible gene was investigated. Then, we aimed to elucidate the responsible gene with reference to previous enuresis history in general populations. But, the genetic analysis had been significantly delayed, so we established an animal experimental model which reflects physiological mechanism of enuresis, and aimed to investigate the responsible gene of enuresis from this approach. As a result, we picked up the candidate gene “PTHrP” as a potent endogenous relaxant of bladder contraction.