Tumor-targeted chemotherapy with the nanopolymer-based drug NC-6004 for oral squamous cell carcinoma

顺铂（CDDP）已成为头颈部鳞状细胞癌（HNSCC）患者化疗的关键药物。肾毒性是其不良反应之一。为了增强其抗肿瘤作用，减少其毒性问题，人们开发了携带CDDP （NC-6004）的聚合物胶束。本研究旨在评价NC-6004的有效性和安全性。为了研究NC-6004的抗肿瘤和肾毒性作用，我们给裸鼠注射了OSC-19。两种药物的抗肿瘤作用相当。CDDP小鼠出现肾细胞凋亡；而注射NC-6004的小鼠几乎没有肾细胞损伤。此外，在原位舌癌模型中，NC-6004使淋巴结转移率低于CDDP。综上所述，考虑到潜在的优势，NC-6004在铂配合物的开发中具有重要的结构改进。

Cisplatin (CDDP) has been a key drug for chemotherapy in patients with head and neck squamous cell carcinoma (HNSCC). Nephrotoxicity is one of its adverse reactions. To increase its antitumor effects and reduce such toxicity problems, polymeric micelles carrying CDDP (NC-6004) have been developed. This study was designed to evaluate the efficacy and safety of NC-6004. To investigate the antitumor and nephrotoxic effects of NC-6004, nude mice bearing OSC-19 were administered drugs. Both drugs showed equivalent antitumor effects. Mice with CDDP developed renal cell apoptosis; however, those injected with NC-6004 were almost free of renal cell injury. Moreover, in an orthotopic tongue cancer model, NC-6004 reduced the rate of lymph node metastasis to lower than that with CDDP. In conclusion, considering the potential advantages, NC-6004 represents a significant structural improvement in the development of a platinum complex.