Development of new therapeutic method of aspiration pneumonitis on saliva protein promoting by PDE

吸入性肺炎的病因是口腔细菌等。唾液蛋白减少口腔细菌等，其表达和分泌受cAMP调控，cAMP受磷酸二酯酶（PDE）控制。大鼠颌下腺主要pde为PDE3和PDE4。PDE3在离体大鼠颌下腺泡细胞中表达，而在导管细胞中不表达。两种细胞均可见肌上皮细胞。PDE3基因敲除小鼠颌下腺无明显变化。PDE4A和PDE7B在颌下腺中表达。提示各PDE调节唾液蛋白的表达和分泌。

Causes of aspiration pneumonitis are oral bacteria et al. Saliva proteins reduce oral bacteria et al, and those expression and secretion are regulated by cAMP, and cAMP are controlled by phosphodiesterase (PDE).In rat submandibular gland main PDEs are PDE3 and PDE4. In isolated rat submandibular acini cells PDE3 was expressed, but not in duct cells. Myoepithelial cells were found in both cells. There were no change in submandibular gland of PDE3 knock out mouse. PDE4A and PDE7B were wxpressed in submandibular gland. It is suggested that each PDE regulated the expression and secretion of saliva protein.