Imaging study of the physiological relationship between dopaminergic neurons and memory central

突触传递的可塑性变化是学习和记忆形成的基础。最近的研究表明，多巴胺在可塑性中起重要作用，但其生理机制尚不清楚。在果蝇中，气味和电击诱导的嗅觉厌恶记忆也需要多巴胺信号。此前，我曾报道过，气味和电击输入的同时刺激通过多巴胺信号在孤立的大脑中诱导蘑菇体--嗅觉记忆中心--的可塑性变化。在这里，我研究了蘑菇体中多巴胺信号与神经可塑性的关系，发现当气味和电击的同时输入激活蘑菇体时，就会发生多巴胺释放。

The plastic change in the synaptic transmission is underlying learning and memory formation. Recent studies have suggested that dopamine is important for the plasticity, while the physiological mechanisms is unclear. In Drosophila, dopamine signaling is also required for olfactory aversive memory that is induced by odor and electrical shock. Previously, I have reported that simultaneous stimulation of odor and shock inputs induced plastic change in the mushroom body, olfactory memory center, in isolated brain via dopamine signaling. Here, I examined the relationship between dopamine signaling and neural plasticity in mushroom body, and found that dopamine release is occurred when mushroom body is activated by simultaneous inputs from odor and shock.