A study of molecular mechanisms of alzheimer's disease caused by endoplasmic reticulum stress.

肥胖和2型糖尿病等代谢性疾病是阿尔茨海默氏症的危险因素。一些研究表明内质网应激在肥胖和糖尿病的发病机制中起作用。然而，Aβ产生的机制仍不清楚。我研究了内质网应激是否促进Aβ的产生，以及从天然提取物中提取的一种IRE1激活化合物--槲皮素的效果。研究发现：(1)内质网应激通过ATF4途径促进Ps1的表达和Aβ的分泌；(2)槲皮素抑制ER应激诱导的ATF4的表达和Aβ的分泌。

Metabolic diseases such as obesity and type-2 diabetes are risk factor for Alzheimer’s disease. Several studies indicate that endoplasmic reticulum (ER) stress contributes to the pathogenesis of obesity and diabetes. However, the mechanism to underlie Aβ production remains to be unknown. I investigated whether ER stress enhances Aβ production, and the effect of an IRE1-activating compound from natural extracts, quercetin. I found that(1) the PS1 expression and Aβ secretion were increased by ER stress through the ATF4(2) quercetin inhibits ER stress-induced ATF4 expression and Aβ secretion.