Role of nutrients against intestinal functions recovery under non-enteral nutrition state

我们分析了营养素非内流导致绒毛萎缩的潜在机制，并使用大鼠营养素非内流模型研究了重新给予营养素是否恢复肠道功能。我们的数据表明，mTOR通路的失活和细胞周期相关基因如细胞周期蛋白的下调与非流入模型动物的绒毛萎缩有关。此外，我们证明了几乎所有与营养物质消化和吸收相关的基因都在重新给予营养物质后显著增加。有趣的是，我们发现，每种营养素类别之间，如碳水化合物，脂质和氨基酸，以及每种营养素质量之间，如葡萄糖，果糖，中链甘油三酯，长链甘油三酯，谷氨酰胺和精氨酸，有不同的效果。

We analyzed underlying mechanism of villus atrophy by non-influx of nutrient, and investigated whether re-administration of nutrient recovers intestinal functions using nutrient non-influx model of rats. Our data suggested that inactivation of mTOR pathway and downregulation of cell cycle related genes such as cyclins are associated with villus atrophy in non-influx model animals. In addition, we demonstrated that almost genes related to digestion and absorption of nutrients significantly increased by re-administration of nutrient. Interestingly, we revealed that there was a different effect between each nutrient category such as carbohydrates, lipids and amino acids and further between each nutrient quality such as glucose, fructose, medium-chain triacylglycerol, long-chain triacylglycerol, glutamine and arginine.