Development of procine model to establish the specific treatment for IgA nephropathy

尽管以扁桃体为中心的粘膜免疫紊乱被认为参与了人类伊加肾病（IgAN）的发病机制，但目前还没有合适的扁桃体动物模型。由于有报道称猪除了具有扁桃体外，还具有类似于人IgAN的自发性肾脏病变，因此我们将猪作为IgAN的新型动物模型。在我们确认微小型猪（MMPs）产生类似于人IgAN以及其他类型的猪的自发性肾脏病变后，我们开始比较自然病程组（自然病程G）和扁桃体切除术组（扁桃体切除术G）中的MMPs之间含有肾脏病变的表型。免疫荧光染色结果显示，8月龄时扁桃体切除组肾小球内MMPs中含有伊加的免疫球蛋白沉积强度可能低于自然病程组。现在我们继续比较表型，重点是肾脏病变。

Though immunological disorders in mucosa with a focus on tonsils are suggested to be involved in the pathogenesis of human IgA nephropathy (IgAN), there are no appropriate animal models bearing tonsils. Since it was reported that porcine develop spontaneous renal lesions resembling human IgAN in addition to bearing tonsils, we focused on porcine as a novel animal models of IgAN. After we confirmed that micro-minipigs (MMPs) develop spontaneous renal lesions resembling human IgAN as well as other types of porcine, we started to compare the phenotype containing renal lesions between MMPs in the natural course group (natural course G) and those in the tonsillectomy group (tonsillectomy G). Immunofluorescence stainings indicated that the intensity of glomerular deposition of immunogloblin containing IgA in MMPs of tonsillectomy G may be lower than that of natural course G at eight months old. Now we are continuing the comparison of phenotype with a focus on renal lesions.