Investigation of Serum Aldosterone Inducing Factors in Patients with Idiopathic Hyperaldosteronism

产醛固酮腺瘤(APA)和双侧特发性醛固酮增多症(IHA)是原发性醛固酮增多症最常见的亚型。本研究表明，仅IHA患者的尿醛固酮分泌与体重指数、腹围、空腹血糖、HOMA-R呈正相关，而与APA和非PA患者无关；IHA患者促进血清醛固酮分泌的能力与患者的醛固酮和内脏脂肪面积呈正相关。

Aldosterone-producing adenoma (APA) and bilateral idiopathic hyperaldosteronism (IHA) are the most common subtypes of primary aldosteronism. The etiology of IHA is still unknown and the radical treatment for IHA is not established.In our study, we have shown that 1) urinary aldosterone secretion positively correlated with body mass index, abdominal circumference, fasting blood glucose and HOMA-R only in patients with IHA, not in APA and non-PA patients and 2)the ability to promote aldosterone secretion by serum of IHA patients positively correlated with patients' aldosterone and visceral fat area.These results suggest that there are CYP11B2 activating factors derived from visceral fat in serum of IHA patients and there is a possibility that IHA is improved by amelioration of obesity.