Basic research for clarifing the phathologic characteristics with HBV genotype A infection

本研究利用细胞培养系统和人肝细胞嵌合小鼠进行基础研究，以阐明乙型肝炎病毒（HBV）基因型A和c的差异。拉米夫定耐药克隆和拉米夫定加恩替卡韦耐药克隆与野生型克隆具有相似的替诺福韦（TDF）敏感性。然而，拉米夫定加阿德福韦耐药克隆获得了对TDF的耐受性。HBV基因A型和基因C型患者对TDF的易感性明显低于基因C型患者。

In the present study, basic research was performed using cell culture system and human hepatocyte chimeric mice for clarifying the differeces between hepatitis B virus (HBV) genotype A and C. Lamivudine-resistant clones and lamivudine plus entecavir-resistant clones had similar tenofovir (TDF) susceptibilities to wild type clones. However, lamivudine plus adefovir-resistant clones acquired tolerance to TDF. Comparing between HBV genotype A and genotype C, the susceptibility to TDF in HBV genotype A was lower than that in HBV genotype C.