Early detection of acute kidney injury following organ transplantation and assessment of recovery using new markers

入院时（n=25） p - ngal、U-NGAL/Cr和L-FABP/Cr与急性肾损伤（AKI）发展无关（p分别为0.24、0.22和0.53）。从第1天到第6天，未从AKI中恢复的患者和从AKI中恢复的患者之间的p - ngal、U-NGAL/Cr和L-FABP/Cr水平没有差异（p分别= 0.82、0.26和0.61）。我们的研究结果表明，ICU入院时的NGAL和L-FABP不能预测AKI，连续的NGAL和L-FABP测量可能对监测移植后AKI的状态和治疗无效。电阻指数（RI）与脉压指数（PI）不相关（n=12），提示在使用RI预测AKI时不一定要考虑PI。我们报道了术前体液平衡调整肌酐水平可以提高心脏手术后AKI诊断的准确性。

P-NGAL, U-NGAL/Cr and L-FABP/Cr upon ICU admission (n=25) were unrelated to acute kidney injury (AKI) development (p = 0.24, 0.22, and 0.53, respectively). There were no differences in P-NGAL, U-NGAL/Cr, and L-FABP/Cr levels from day 1 to day 6 between patients who did not recover from AKI and patients who recovered from AKI (p = 0.82, 0.26, and 0.61, respectively). Our findings suggest that NGAL and L-FABP upon ICU admission are not predictive of AKI and serial NGAL and L-FABP measurements may be ineffective for monitoring the status and treatment of post transplantation AKI. The resistive index (RI) did not correlate with pulse pressure index (PI) (n=12), suggesting that PI may not be necessarily considered when predicting AKI using RI. We reported that adjustment of creatinine level for preoperative fluid balance could improve the accuracy of AKI diagnosis after cardiac surgery.