Differentiation induction from embryonic stem cells to functional thyroid tissues

我们的目标是，比利时的Antonica博士等人在2012年完成了从胚胎干细胞向甲状腺组织的分化诱导，并移植到小鼠体内，从而恢复了甲状腺功能（Nature 491（7422）：66-71.2012）。我们推测这种分化效果与胚胎干细胞维持未分化状态的能力之间存在重要关系。我们进一步分析它以提高胚胎干细胞的分化诱导效率。结果表明，肝受体同源物1（LRH 1），我们专门检查，直接诱导Sox 2和Gabp。它在自我更新中发挥了重要作用。

Differentiation induction from embryonic stem cells to thyroid tissues, which we is our objective, was accomplished by Dr. Antonica and others from Belgium in 2012, leading to transplantation into the body of a mouse and thus to recovery of thyroid function (Nature 491(7422):66-71.2012).We inferred an important relation between this differentiation efficacy and the potency of embryonic stem cells to maintain the undifferentiated state. We analyzed it further to improve the differentiation induction efficacy of embryonic stem cells. Results demonstrated that the liver receptor homologue 1 (LRH1), which we specifically examined, was induced directly by Sox2 and Gabp. It played an important role in self renewal.