课题基金 / 基金详情

Research of oxidative stress and mitochondrial gene polymorphism in presbycusis

Research of oxidative stress and mitochondrial gene polymorphism in presbycusis
老年性耳聋氧化应激与线粒体基因多态性研究
批准号:
24791802
负责人:
SHIMAMOTO Kirito
金额:
$2.25万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31

项目摘要

项目成果

相关文献

中文摘要
翻译
老年性耳聋组有13个OXHOS基因位于构造区,包括线粒体12SrRNA,差异有统计学意义。另一方面,BAP值与年龄成正比(平均833nmol/L),与SNP无相关性。在SNP的背景下也没有观察到D-ROM值。由于还有地震的影响,门诊就诊人数减少,可以成为目标的病例减少了,确保了受试者数量少于预期。在研究过程中也存在着一些影响,在一个个地震目标的方向上,也存在着明显的生命失败的原因,今后,我们要把支持作为保障农村地区目标的重要事项与研究体系一起来进行。
英文摘要
13 genes OXHOS site at the construction area, including the mitochondrial 12SrRNA was statistically significant in presbycusis group. On the other hand, BAP values were found low levels of BAP values (average 833 nano mol/l) in proportion to age, there was no correlation with the SNP. d-ROM value was also not observed in the context of the SNP as well.Because there is the influence of the earthquake also, a decrease in outpatient visits number of patients, cases that can be a target has been reduced, ensuring the number of subjects was less than expected. There is also some influence in the research process one by one earthquake in the direction of the target, and also conspicuous failure of the life of the cause, in the future, we would like to support as important matters to ensure the target in rural areas along with the research system .
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会议论文
老人性難聴に関するミトコンドリア遺伝子と酸化ストレスの検討
与老年性耳聋相关的线粒体基因和氧化应激检查
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [竹井 慎, 荒井 潤, 保富宗城, 山中 昇, 玉川 俊次, 玉川俊次, 嶋本記里人]
通讯作者: 嶋本記里人