The role of neural crest-derived cells in skin wound healing

这项研究的目的是阐明神经沟来源的细胞在皮肤中的命运及其在皮肤伤口愈合中的作用。使用两种神经脊细胞特异性表达GFP的小鼠(P0-CRE+FLOX-CAT-EGFP小鼠，WNT1-CRE+FLOX-CAT-EGFP小鼠)，我们发现它们可以分化为黑素细胞、真皮鞘细胞、毛乳头细胞、神经元和脂肪细胞。在创面愈合过程中，有GFP阳性的内皮细胞、肌成纤维细胞和角质形成细胞，说明神经脊来源的细胞受到一定创伤信号的刺激，参与皮肤创面的愈合。

The purpose of this study was to elucidate the fate of neural crest-derived cells in the skin and their roles in skin wound healing. Using the two strain of mice in which neural crest-derived cells specifically express GFP (P0-Cre+ flox-CAT-EGFP mice, Wnt1-Cre+ flox-CAT-EGFP mice), we have shown that they differentiate into melanocytes, dermal sheath cells, dermal papilla cells, neurons, and adipocytes. During wound healing process, there were GFP-positive endothelial cells, myofibroblasts, and keratinocytes, demonstrating that neural crest-derived cells are stimulated by some wound signal and contribute to skin wound healing.