Development of novel platform for injectable in vivo drug delivery system

我们研究的最终目标是：（1）发现下一代感染性疾病和癌症治疗生物医学的种子;（2）开发支持外科治疗的生物相容性材料。本研究以脊椎动物普遍表达的弹性纤维蛋白弹性蛋白为研究对象。我们进行了合理的设计和重组合成的热响应肽聚合物为基础的水凝胶组成的弹性蛋白样多肽，迅速形成可逆交联的水凝胶通过形成分子间温和的氧化交联。我们展示了水凝胶用于药物缓释的实用性以及作为可注射和可生物降解材料的能力。这些材料将在药物输送和组织工程中找到有用的应用。

The final goal of our study is: (1) to discover the seeds of next-generation biomedicine for infectious disease and cancer therapy; (2) to develop biocompatible materials for supporting surgical treatment. In this study, we focused elastin protein which expresses universally as an elastic fiber of vertebrates. We carried out the rational design and recombinant synthesis of thermally responsive peptide polymer-based hydrogels composed of an elastin-like polypeptide that rapidly forms a reversibly cross-linked hydrogel by the formation of intermolecular mild oxidative cross-links. We showed the utility of the hydrogels for the sustained release of medicines and the ability as to be an injectable and biodegradable material. These materials will find useful application in drug delivery and tissue engineering.