Analysis of p3-Alc peptides, the novel biomarker for Alzheimer's disease

阿尔茨海默病（AD）是最常见的老年性痴呆。然而，阿尔茨海默病的发病机制尚不清楚。此外，阿尔茨海默病的早期发现方法和根本治疗方法尚未完全建立。在本研究中，我从AD患者的脑脊液样本和血浆样本中检测了p3-Alc肽。我们的研究结果表明，在一些AD患者中可能出现多种γ -分泌酶底物的替代加工。这些发现提高了AD的分子发病机制可能与γ分泌酶功能障碍有关的可能性。测量p3-Alc水平可能有助于选择可能受益于以调节γ分泌酶功能为目标的患者特异性治疗的受试者。

Alzheimerz's disease (AD) is the most common senile dementia. However, the pathogenesis of AD remains unclear. Moreover, early detection methods and fundamental therapeutic methods for AD are not fully established.In this study, I detected p3-Alc peptides from CSF samples and plasma samples of AD patients. Our results suggest that alternative processing of multiple gamma-secretase substrates may occur in some AD patients. These finding raise the possibility that the molecular pathogenesis of AD might involve gamma-secretase dysfunction. Measurement of p3-Alc levels may be useful in selecting subjects that might benefit from patient-specific therapy aimed at modulation of gamma-secretase function.