Development of lipid bilayer membrane vesicles constructed by fat-soluble vitamin and application for cancer treatment

在这项研究中，我们确定了含有胆钙素衍生物的脂质体与细胞表面的小窝蛋白-1相互作用，并通过小窝介导的内吞作用进入细胞。此外，我们还发现含有胆钙素衍生物的脂质体具有细胞毒活性，并提高了抗癌药物等其他药物的药理活性。由于本研究中使用的胆钙素衍生物已经研究了其在体内的代谢和消除过程，因此这些成分具有很高的生物相容性。因此，本研究获得的这些结果有助于药物开发，为构建有效、安全的用药提供参考。

In this study, we determined that cholecalciferol-derivative containing liposomes are interacted with caveolin-1 on the cell surface, and taken up into the cells via caveolae-mediated endocytosis. Moreover, we showed that cholecalciferol-derivative containing liposomes possess the cytotoxic activities, and increase the pharmaceutical activities of the other medicines such as anti-cancer agents. Since the cholecalciferol-derivatives used in this study have already been investigated the metabolic and eliminating process in the body, these components have high biocompatibility. Therefore, these results obtained from this study contribute to pharmaceutical development for the construction of effective and safe medication.