Carbon monoxide-bound hemoglobin-vesicles as a potential therapeutic agent for the treatment of bleomycin-induced pulmonary fibrosis

一氧化碳（CO）具有有效的抗炎和抗氧化作用。我们制备了co结合的血红蛋白囊泡（CO-HbV），并评估了CO-HbV对特发性肺纤维化（IPF）的治疗效果，IPF被认为涉及炎症和活性氧（ROS）的产生。在博来霉素诱导的肺纤维化小鼠模型中，与生理盐水和HbV相比，CO-HbV抑制肺原纤维形成的进展并改善呼吸功能。CO-HbV对肺纤维化的抑制作用可归因于肺中炎症细胞、细胞因子和转化生长因子- β生成ROS的减少。在博莱霉素诱导的肺纤维化小鼠模型中，这是CO- hbv通过CO的抗氧化和抗炎作用首次证明了CO- hbv对肺纤维化进展的抑制作用。

Carbon monoxide (CO) has potent anti-inflammatory and anti-oxidant effects. We preparate a CO-bound hemoglobin-vesicles (CO-HbV), and evaluated the therapeutic effect of CO-HbV on idiopathic pulmonary fibrosis (IPF) that is thought to involve inflammation and the production of reactive oxygen species (ROS). CO-HbV suppressed the progression of pulmonary fibril formation and improved respiratory function compared to saline and HbV in a bleomycin-induced pulmonary fibrosis mice model. The suppressive effect of CO-HbV on pulmonary fibrosis can be attributed to a decrease in ROS generation by inflammatory cells, cytokines and transforming growth factor-beta in the lung. This is the first demonstration of the inhibitory effect of CO-HbV on the progression of pulmonary fibrosis via the anti-oxidative and anti-inflammatory effects of CO in the bleomycin-induced pulmonary fibrosis mice model.