Supporting characters may go to the heart of amyloidogenesis: Amyloid associated protein world

众所周知，一些与淀粉样蛋白原纤维共定位的蛋白，即淀粉样蛋白相关蛋白，可能在淀粉样变性中起重要作用。然后，我们试图在本研究中挑选出强有力的候选物作为淀粉样变性的早期诊断标记和/或治疗分子。根据我们的研究结果，我们可以检测到一些强有力的候选物质，如clusterin和vitronectin。家族性淀粉样变性多神经病变（FAP）患者血清聚簇蛋白水平明显高于健康志愿者。此外，FAP患者心脏组织中玻璃体粘连蛋白与TTR沉积的相关性显著升高。

It is well known that some co-localized proteins with amyloid fibrils, which are called amyloid associated proteins, may play important roles in amyloidosis. Then, we tried to pick up the strong candidates as early diagnostic markers and/or therapeutic molecules of amyloidosis in this study. As the results of our studies, we could detect some strong candidates, such as clusterin and vitronectin. Serum clusterin levels of familial amyloidotic polyneuropathy (FAP) patients was significantly higher than that of healthy volunteers. Moreover, significant higher correlation between vitronectin and TTR deposition was observed in the cardiac tissues of FAP patients.