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Whether or not exercise in the juvenile period prevents depression-like behaviour in the maturation period via epigenetic gene regulation

Whether or not exercise in the juvenile period prevents depression-like behaviour in the maturation period via epigenetic gene regulation
青少年时期的锻炼是否可以通过表观遗传基因调控来预防成熟期的抑郁样行为
批准号:
24700714
负责人:
NAKAJIMA SANAE
金额:
$2.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31

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中文摘要
翻译
在幼年期定期运动的抗抑郁作用是用在生长季节没有进行任何运动的小鼠和在幼年期进行定期运动的小鼠,通过在成熟期给予它们心理应激来检查的。从行为实验,这是确定抑郁症的行为变化和可接受性实验的结果,表明在青少年期定期锻炼,可以缓解抑郁症的行为变化的可能性。然而,各组海马神经发生无显著变化。方法学的建立需要较长的时间,研究还没有到比较研究是否存在表观遗传突变的阶段。
英文摘要
The antidepressant effect of regular exercise in the juvenile period were examined with the mice had not done any exercises during the growing season and the mice had done regular exercise in the juvenile period, by giving them a psychological stress during the period of maturity. From the result of behavioral experiments, which was to determine the behavioral changes during depression and acceptability experiments, the possibility of regular exercise in the juvenile period that can ease behavioral changes during depression was indicated. However, no significant change in neurogenesis of the hippocampal was observed from each group. It requires more time to establish the methodology, the research was not at the stage of comparative investigation whether there was any epigenetic mutation or not.
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