Bionic Transdermal Patch

我们报道了一种透皮生物燃料电池贴片，它由用于果糖氧化的生物阳极织物、装有果糖燃料和化合物(罗丹明B和抗坏血酸葡萄糖苷(AG))的水凝胶罐、O2扩散生物催化纤维和离子隔离疏水火焰组成。当贴片安装在哺乳动物皮肤上时，贴片在皮肤上的阳极和阴极之间产生约140微安厘米-2的离子电流。这种离子电流可以通过设置外部电阻来控制。外加电流在5微安厘米-2的小电流下诱导约7.7微升厘米-2的水向阴极流动1小时，然后辅助化学药物进入皮肤(例如。在阳极侧，AG在表皮内输送20微克厘米-2，在真皮内输送2.5微克厘米-2)。

We report here a transdermal biofuel cell patch that is composed of bioanode fabrics for fructose oxidation, hydrogel tanks containing fructose fuel and chemical compounds (Rhodamine B and ascorbyl glucoside (AG)), O2-diffusion biocathode fabrics, and an ion-isolating hydrophobic flame. When the patch is mounted on the mammalian skin, the patch generate the ionic current of ca.140 microampere cm-2 between the anode and the cathode across the skin. This ion current could be controlled by setting up the external resistance. The applied current induced a water flow of ca. 7.7 microliter cm-2 for 1 h at small current of 5 microampere cm-2 toward the cathode, and then assisted a chemical administration into the skin (ex. AG delivery of 20 microgram cm-2 within the epidermis and 2.5 microgram cm-2 within the dermis) at the anodic side.