SPP 1029: Die Rolle von Mikrogliazellen bei Erkrankungen des Nervensystems

中枢神经系统疾病，如阿尔茨海默氏病或中风，在我们现代西方社会的人口结构中变得越来越重要。因此，对中枢神经系统病理过程的基本分子和细胞机制的理解成为神经科学研究的一个突出目标。中枢神经系统损伤或损伤后小胶质细胞活化是一种普遍的反应模式，无论神经变性的类型如何。小胶质细胞是造血来源的，并且侵入CNS。它们通过与其他胶质细胞、神经元以及入侵血细胞相互作用来影响变性过程。小胶质细胞活化过程的分子基础和与其他细胞的相互作用是一个非常年轻的研究领域，从中可能产生新的概念来理解CNS疾病的发病机制，无论是早期诊断还是治疗。这一课题需要跨学科的方法，因为它包括分子水平的基础研究以及临床研究。这一研究领域在过去几年中迅速发展，这一领域的出版物增加。

Disorders of the central nervous system such as Alzheimer's disease orstroke become increasingly important with respect to population structure in our modern Western society. The understanding of the basic molecular and cellular mechanisms of pathological processes in the central nervous system thus became a prominent target in neuroscience research. Microglia activation after damage or injury of the central nervous system is a universal reaction pattern, regardless the type of neurodegeneration. Microglial cells are of hematogenic origin and invade the CNS. They influence the process of degeneration by interacting with other glial cells, neurons but also invading blood cells. The molecular basis of the activation process and the interactions of microglia with other cells is a very young field of research, from which new concepts may arise to understand thepathogenesis of CNS diseases, both for early diagnosis, and for therapy. This topic requires an interdisciplinary approach, since it embraces basic research on the level of the molecule as well as clinical research. This field of research rapidly developed within the last years which is documented by the increase in publications from this field.