SPP 1110: Innate Immunity

先天免疫包括一个细胞和可溶性因子网络，可以在最初的几个小时和几天内保护宿主免受病原微生物的入侵。 先天免疫的第二个重要作用是建立一个框架，用于启动适应性抗原特异性免疫应答。病原体来源的抗原通过先天免疫系统的不同组分的空间和时间协调作用的初始摄取和加工在为平衡的适应性免疫应答设置阶段中起关键作用。“先天免疫”优先方案将分散在不同地区的各个领域的专家聚集在一起，重点研究四个专题：（1）被先天免疫系统识别为“外来”的病原体相关模式的鉴定和结构-功能表征，（2）先天免疫系统细胞表达的模式识别受体的鉴定和结构-功能表征，所述模式识别受体对先天和随后的适应性免疫应答的启动和协调至关重要，（3）先天免疫系统的细胞内和细胞间效应器机制的调节，（4）先天免疫在感染性疾病免疫发病机制中的作用。以基础科学为导向的优先方案旨在进一步了解触发先天免疫的分子成分的功能作用，以提供调节先天和适应性免疫反应的特定效应机制的信号。

Innate immunity comprehends a network of cells and soluble factors that defend the host in the first hours and days against invading pathogenic microorganisms. A second important role of innate immunity is to establish a framework for the inititation of an adaptive, antigen-specific immune response. The initial uptake and processing of pathogen-derived antigens through a spatially and temporally coordinated action of diverse components of the innate immune system plays a pivotal role in setting the stage for a balanced adaptive immune response. The priority programme "Innate Immunity" brings together geographically dispersed experts in the various fields to focus on four research topics:(1) Identification and structural-functional characterization of pathogen-associated patterns that are recognized by the innate immune system as "foreign",(2) Identification and structural-functional characterization of pattern recognition receptors expressed by cells of the innate immune system that are pivotal to the initiation and coordination of the innate and subsequent adaptive immune response,(3) Regulation of intra- and intercellular effector mechanisms of the innate immune system,(4) The role of innate immunity for the immunopathogenesis of infectious disease. The basic science-oriented priority programme is meant to further our understanding of the functional roles of molecular components triggering innate immunity to provide signals that regulate particular effector mechanisms of both innate and adaptive immune responses.