Arrays of Amphiphilic Metal Complexes for Guided Molecular Recognition at Interfaces

功能化接口是感兴趣的传感器或复杂的材料，但他们的定义制备仍然是一个挑战。在这个项目中，我们结合了自组装单层和超薄Langmuir Blodgett薄膜的双层制备技术，这种技术允许高度平面内控制空间条件，以及两亲性金属配合物结合位点，在水介质中对某些官能团提供特异性和高亲和力。得到的有序金属配合物结合位点的表面用于引导核苷酸在附加层中的自组装，产生高度复杂但定义良好的表面结构。通过修饰金属配合物结合位点及其在界面中的排列，以及使用不同的核苷酸和寡核苷酸在表面上进行引导组装，探索了组装过程对表面结构的依赖性。由于在表面嵌入了多种结合位点，表面图案的形成成为可能。这样的表面可能表现出增强的结合选择性。我们将探索不同层组成对表面结合的影响，并在层形成过程中使用模板分子预组织结合位点。反应性二乙炔两亲分子允许在聚二乙炔薄膜中保留组装图案。

Functionalized interfaces are of interest as sensors or sophisticated materials, but their defined preparation is still a challenge. In this project we combine the technique of double layer preparation from self-assembled monolayers and ultrathin Langmuir Blodgett films, which allows a high in-plane control of steric conditions, with amphiphilic metal complex binding sites, providing specific and high affinity to certain functional groups in aqueous media. The so obtained surfaces of ordered metal complex binding sites are used for guided self-assembly of nucleotides in additional layers yielding highly complex, but well defined surface structures. The dependence of the assembly process on the surface structure is explored by modification of the metal complex binding sites and their arrangement in the interface, and by the use of different nucleotides and oligonucleotides for the guided assembly on the surface. With more than one kind of binding site embedded in the surface, the formation of surface patterns becomes possible. Such surfaces may show enhanced binding selectivities. We will explore the effect of different layer compositions on the binding on surface and use template molecules to preorganize binding sites during the layer formation process. Reactive diacetylene amphiphiles allow retaining assembled patterns in a polydiacetylene film.