バイオミメティックポリエン環化反応に有効な超分子触媒の設計

在羰基烯环化和串联缩醛化催化剂设计的基础上，我们正在探索适合于不对称多烯环化的催化剂体系。目前，我们的重点是设计用于单环环化的LBA催化剂，并希望在不久的将来将其进一步扩展到多烯或功能多烯。我们已经探索了手性磷酸与不同路易斯酸的几种组合，以检验下面的反应。到目前为止，我们在标准反应的初步筛选中已经取得了良好的E/Z选择性和中等的对映体选择性。

At the base of the previous work of catalyst design in carbonyl-ene cyclization & tandem acetalization, we are exploring the proper catalyst systems for the asymmetric polyene cyclization. At first, we are focusing on the design of the LBA catalyst for the cyclization in the single-ring formation and wish to further expand it to the polyenes or functional polyenes in the near future. We’ve explored several combinations of the chiral phosphoric acids with diverse Lewis acids to examine the reaction below. So far, we’ve already succeeded the excellent E/Z selectivity and moderate enantioselectivity in the initial screening of the standard reaction.