A study of elucidating the effects of exercise on muscle Na-K pump in hypokalemia

在这份报告中，我们调查了（1）低骨骼肌肉Na-K泵对低骨骼和糖尿病大鼠的耐久性训练的影响， （2）观察肌肉潜力与肥胖和肥胖相关的频率反应。训练和非训练组是由Deionized水和KI-D1 + D1-deficient饮食引起的。训练组的老鼠在跑步机上训练了12米/分钟，每星期3次，持续30分钟。距离老鼠可以运行，等离子体Kyi D1+ Kyi D1含量，训练老鼠在大约6周后的训练中明显比那些未经训练的老鼠大。Intracellular K-D1 + K-D1 content （[K] K-D2i-D2 ） in the EDL and the SOL of the trained rats was also significantly greater than that of the untrained ones。The decrease of [K]イD2iイエD2 in lower skeletal muscle induced by stimulation of sciatic nerve was significantly greater in the untrained rats than in the trained ones.These results indicate that the endurance training based on aerobic exercise delays the progress of hypokalemia in rats fed the KイイD1+イエD1-deficient diet，以及训练场在防止等离子体KI-D1 + I-D1退化线中激活的Na-K泵的重要作用。正常大鼠中EDL和SOL的断点频率为85赫兹和15赫兹，尊敬的。它们减少到15赫兹和5赫兹，适当地减少到15赫兹。这些结果提出一个结论，即对引起的潜力的频率反应是对morbid nerve-muscle的评估的一个有用的指数。

In this report, we investigated (1) effects of endurance training on lower skeletal muscle Na-K pump of hypokalemic and diabetic rats, (2) frequency response of evoked muscle potential relating to fatigue and hypokalemia.Rats of training and non-training groups were bred with deionized water and a KィイD1+ィエD1-deficient diet. The training group rats were trained with a treadmill running at 12 m/min for 30 minutes, 3 times a week.The distance rats could run, plasma KィイD1+ィエD1 content and lactate threshold of the trained rats after about 6 weeks' training were significantly greater than those of the untrained ones. Intracellular KィイD1+ィエD1 content ([K]ィイD2iィエD2 ) in the EDL and the SOL of the trained rats was also significantly greater than that of the untrained ones. The decrease of [K]ィイD2iィエD2 in lower skeletal muscle induced by stimulation of sciatic nerve was significantly greater in the untrained rats than in the trained ones.These results indicate that the endurance training based on aerobic exercise delays the progress of hypokalemia in rats fed the KィイD1+ィエD1 -deficient diet, and that the Na-K pump in muscle cells activated by training plays an important role in protecting against the decline in plasma KィイD1+ィエD1.The break-point frequencies of EDL and SOL were 85 Hz and 15 Hz in normal rats, respectively. They decreased to 15 Hz and 5 Hz in hypokalemic rats, respectively. These results suggest that the frequency response of evoked potential is an useful index for evaluation of morbid nerve-muscle.