Study on Thrapeutic Drug Monitoring Simulation Program

近年来，计算环境在硬件和软件方面都得到了迅速的发展。医学信息处理很可能在临床和药学中有用，而药物信息处理则有助于更基础的研究。医学和药学信息学的教育方法论尚未建立。将这些教育方法系统化将是至关重要的。另一方面，药物监测(TDM)是为了合理、良好的用药和生活质量而进行的。药物血药浓度的模拟程序通常比较复杂。医生、药剂师和患者将需要一个通用的TDM模拟程序。在本研究中，我们构建了药物信息数据库和便于教育和临床应用的TDM模拟程序。时分复用仿真程序用Microsoft Visual Basic编制。三种动力(线性1隔间，非L…共享了更多的线性单室和线性两室模型。以苯巴比妥、卡马西平、丙戊酸盐、苯妥英钠、利多卡因、阿米卡星为模型药物。该程序可以自由改变一些动力学参数，只需点击一个按钮，就可以非常容易地绘制出血药浓度曲线。日本药学会第118届年会(1998年3月，京都)介绍了部分研究结果。Microsoft Access97制作了患者用药说明表的编制数据库，涵盖了1200多种药物信息，包括用法、疗效、不良后遗症和注意事项。这个应用程序可能有助于药剂师告发病人。在日本药学会第119届年会(1999年3月，德岛)上介绍了部分成果。这两个应用程序在我们学院的课程中使用，受到了学生的高度评价。对于医药信息学的评估和系统化，这些程序的改进和其他工具的开发也在进行中。较少

Recently, computing envilopments have been developed rapidly in both hardwares and softwares. It is likely that the medical information processing is useful in clinics and pharmacy, pharmaceutical information processing is helpful in the more basic researches. The educational methodology of the medical and pharmceutical infomatics has not been established. It will be essential to systematize these educational methods. On the other hand, the thrapeutic drug monitoring (TDM) are carried out for a suitable and good drug usage and a Quality of life. The simulation programs for the concentration of drugs in blood are complicatted commonly. A general-purpose program of TDM simulation will be required for doctors, pharmacists and patients. In this study, we constract the database of the drug information and the facile TDM simulation program for the educational and clinical applications.1. The TDM simulation program was made by Microsoft Visual Basic. Three kinetic (linear 1-compartment, non-l … More inear 1-compartment and linear 2-compartments) models were shared. Phenobarbital, carbamazepine, valproate, phenytoin, lidocaine, and amikacin were constructed as model drugs. This progam was able to change some kinetic parameters freely and the drug concentration curves in blood drawed very easy, only by clicking one button. A part of the results was presented in the 118th anual meeting of the Pharmaceutical Society of Japan (Mar., 1998, Kyoto).2. Microsoft Access97 made the database of the preparation of lnfrrming sheets for the drug information for patients, that covered about 1200 drug informations, namely the usages, efficacies, harmful aftereffects and notes. This application may be useful for informing against patients by pharmacists. A part of the results was presented in the 119th anual meeting of the Pharmaceutical Society of Japan (Mar., 1999, Tokushima).3. The two application programs were used in the curriculum of our Faculty and highly regarded by the students. For the estimation and systematization of the medical and pharmaceutical informatics, the improvements of these programs and the developments of other tools are progressed. Less