The Effect of Progressive Muscle Relaxation with Music for Nausea and Vomiting Related to Chemotherapy : in Concerning about Anxiety, Age, and Natural Killer Cell Activity

本研究旨在探讨音乐疗法(M)配合渐进性肌肉松弛疗法(PMR)的效果，恶心/呕吐/干燥症(NVR)与年龄、焦虑的关系，NVR与各周期的关系，自然杀伤细胞活性(Nkact)、白细胞、生长激素等指标的变化。研究对象为M大学医院及两所综合性医院住院接受化疗的癌症患者35例(试验组20例，对照组15例)。平均年龄为54.3岁。结果显示，PMR对M的疗效有上升趋势，但没有统计学意义。NVR值实验组为2.313分，对照组为3.466分。而在大学医院的患者具有PMR与M的有效性(p&lt；0.05)。大学医院的患者平均年龄比两家医院的患者年轻10岁。NVR与年龄的关系显示，年轻患者的NVR比老年患者严重(r=-.534)。因此，年轻患者的NVR可能比老年患者更严重，PMR的效果更好。NVR与焦虑之间的关系没有统计学意义。但该大学的患者显示，NVR越严重，焦虑(状态)越强(r=0.68)。周期1的NVR评分高于周期2和周期3。因此，护士应帮助患者在周期1中不经历严重的NVR，也不要有强烈的焦虑。由于没有足够的数据可供分析，本文没有显示M与PMR联合使用时Nkact、白细胞、生长激素等的变化。因此，这项研究一直在继续。

This study was to examine about 1) the effect of progressive muscle relaxation (PMR) with music therapy (M), 2) the relationships among nausea/vomiting/retching (NVR), age, and anxiety, 3) the relationship between NVR and each cycle, and 4) the change of natural killer cell activity (Nkact), white blood cell, growth hormone, and others in using PMR with M.Subjects are 35 hospitalized cancer patients having chemotherapy (experimental group : 20, control group : 15) at M University hospital and two general hospitals. The average age was 54.3 years old.The result showed the trend of the effectiveness of PMR with M, although it was not statistically significant. The scores of NVR were 2.313 for the experimental group and 3.466 for the control group. But the patients at the university hospital had the effectiveness of PMR with M (p<.05). The average age of the patients at the university hospital was 10 years younger than the patients at two hospitals. And the relationship between NVR and age showed that the younger patients had severer NVR than the older patients (r=-.534). Thus, the younger patients may have severer NVR and get more effect of PMR than the older patients.There was not statistically significance for the relationship between NVR and anxiety. But the patients at the university showed that the severer NVR was, the stronger anxiety (state) was (r=.68). And Cycle 1 showed more scores of NVR than cycle 2 and cycle 3. Thus, it is important for nurse to help the patients not to experience sever NVR at cycle 1 and also not to have strong anxiety.The change of Nkact, white blood cell, growth hormone, and others in using PMR with M has not been shown here because there were not enough data to analyze. Therefore, this study has been continuing.