Fast magnetic resonance imaging for analysis of gastrointestinal function in health and disease

应用快速磁共振成像技术分析健康和疾病时胃肠道的功能。使用具有鸟笼RF线圈（内径为10和20 μ m）的4.7T磁共振光谱仪（Biospec ABX 47/40，Bruker）进行兔食管/狗胃和大鼠胰腺的IH成像，以实现三个主要目的：（1）成像速度，（2）长期记录和（3）高分辨率（MR显微术）。通过快速梯度回波成像（快照）拍摄动物的横向、矢状和冠状图像。通过快照方法（FOV 225^2 mm数据矩阵96^2，层厚6 mm，TR 3.4 ms，TE 1.9 ms，329 ms/图像）清晰地显示了8.3 cm/s的食管蠕动运动。同步测压分析证实MR图像为食管收缩.使用实时MR图像重建系统和视频记录器（MR视频系统）对填充有0.3%柠檬酸铁铵的犬胃进行连续记录。实时胃蠕动图像可记录20 min以上，每幅图像0.45 s（FOV 300^2 mm，matrix 128^2，层厚6 mm，TR 3.4 ms，TE 1.8 ms）.大鼠急性实验性胰腺炎后，在不控制呼吸的情况下，每隔5-7天对胰腺进行一次MR成像（FOV 100 mm，matrix 256 × 2，层厚3 mm，TR 6.8 ms，TE 3.5 ms）。胰腺炎性改变和囊肿的时空发展可显示为三维图像。

Fast magnetic resonance (MR) imaging techniques were applied to analyze the function of the gastrointestinal tract in health and disease. iH imaging of the rabbit esophagus/dog stomach and rat pancreas was carried out using a 4.7 T magnetic resonance spectrometer (Biospec ABX 47/40, Bruker) with bird-cage RF coils (inner diameters of 10 and 20 em) to achieve three main objectives ; (1) speed of imaging, (2) long-term recording and (3) high resolution (MRmicroscopy). Transverse, sagittal and coronal images of the animals were taken by fast gradient-echo imaging (Snapshot).1. Esophageal peristaltic movement at 8.3 cm/s was clearly visualized by Snapshot method (FOV 225^2 mm data matrix 96^2, slice thickness 6 mm, TR 3.4 ms, TE 1.9 ms, 329 ms/image). Simultaneous manometric analysis confirmed MR image was esophageal contraction.2. A continuous recording of the dog stomach filled with 0.3% ferric ammonium citrate,was carried out using a real-time MR image reconstruction system and a video recorder (MR video system). Real-time images of gastric peristaltic movement could be recorded at 0.45 s/image for over 20 min (FOV 300^2mm, matrix 128^2, thickness 6 mm, TR 3.4 ms, TE 1.8 ms).3. MR imagingofthe rat pancreas (FOV 100 mm, matrix 256^2, thickness 3 mm, TR 6.8 ms, TE 3.5 ms) after acute experimental pancreatitis was successfully conducted at 5-7 days intervals for one month without controlling breathing. Inflammatory changes of the pancreas and the spatial and temporal development of a cyst could be seen as three dimensional images.