Evaluation of newly developed heat liquid injector and its basic study

经皮乙醇注射疗法（PEIT）已被广泛接受用于治疗肝细胞癌（HCC）。然而，一次注射的乙醇量有限，需要反复注射才能获得足够的效果，这限制了其应用于小于3个直径小于3cm的HCC结节。我们研制了一种装置，利用该装置可以在超声引导下安全、准确地将加热后的乙醇注射到肿瘤结节内，我们得到了以下结果。(1)当乙醇注射温度达到60℃时，70℃对大鼠肝脏的坏死作用较室温明显增强。(2)醋酸注射组坏死体积在5%、20%、30%、50%组间差异有统计学意义（P<0.05）。当乙酸浓度为10%时，50℃、70℃和100℃下各组坏死体积差异有统计学意义（P<0.05）。(3)经加热的醋酸注射，即使在低浓度下也有很强的坏死性作用。

Percutaneous ethanol injection therapy (PEIT) has been widely accepted for the treatment of hepatocellular carcinoma (HCC). However, the limited volume of ethanol in one shot requires repeated injections to attain adequate results, restricting its application to less than 3 HCC nodules of less than 3 cm in diameter. We developed a device in which heated ethanol can be injected into tumor nodules safely and accurately under ultrasonic guidance using this device, we got the following results.(1)When the temperature of ethanol injected reached 60℃, 70℃ the necrotic effects on the rat liver were markedly increased compared to those at room temperature.(2)For injection of acetic acid, significant differences (P<0.05) were observed in volume of necrosis among groupes administered 5%, 20%, 30% and 50%. For 10% acetic acid, significant differences (P<0.05) were obseved in volume of necrosis among groups at 50℃, 70℃ and 100℃.(3)It was shown that with injection of heated acetic acid, a strong necrotizing effect was obtained even at a low concentration.