GRK 1563: Regulation and Evolution of Cellular Systems

国际研究培训小组汇集了来自慕尼黑两所大学（慕尼黑大学和慕尼黑工业大学）和莫斯科国立大学的研究人员。该研究计划的中心主题是细胞系统的调节和进化，旨在联合来自多个学科的研究小组，促进理论家和实验家之间的合作，基于高通量表达数据，模拟和理解物种之间调节网络的逻辑和定量行为的异同。核心研究问题是通过实现我们的方法的工作流程方案，主要关注在各个项目之间共享的磷酸化蛋白质组学数据。在此框架下，有三个主要的研究课题：(1)代谢和调控系统的比较基因组学；(2)基于网络的转录组和蛋白质组数据解释；(3)转录后调控机制。研究培训小组鼓励各实验室之间的知识和人员交流，产生协同效应，使系统生物学等非常复杂的新兴领域取得更大进展。研究培训小组的中心是一个研究生项目，旨在培养理解复杂生物系统所需的所有领域的博士生。该计划建立在慕尼黑自2000年以来和莫斯科自2002年以来提供的生物信息学非常成功的学士/硕士/文凭课程的基础上。研究培训小组博士课程的优势在于，它形成了一个研究生网络，用不同的跨学科工具解决一系列共同的问题。这是通过研究培训小组的实施和创新概念来确保中央研究重点，从而实现和要求有竞争力的个人博士项目以及通过共享数据和模型进行合作。学生将接受理论和实验培训，并有机会在这三所大学的参与实验室学习专业技能。因此，他们的培训将远远超出通常在单个学术院系或小组内提供的培训。其成果将是新一代的科学家，他们能够探索正在产生的大量基因、基因组和蛋白质组学数据，并将它们整合到对细胞过程如何被调节的新理解中。

The International Research Training Group brings together researchers from two Munich universities (LMU and TUM) and the Moscow State University. The central theme of the research programme, the regulation and evolution of cellular systems, serves to unite research groups from several disciplines and promote collaboration between theoreticians and experimentalists to model and understand similarities and differences in the logic and quantitative behaviour of regulatory networks among species based on high-throughput expression data. The central research question is addressed with a major focus on phosphoproteomics data shared among the individual projects via a workflow scheme implementing our approach. Within this framework, there are three main research topics: (1) comparative genomics of metabolic and regulatory systems; (2) network-based interpretation of transcriptome and proteome data; (3) posttranscriptional regulation mechanisms. The Research Training Group encourages the exchange of knowledge and personnel among various labs, producing a synergistic effect that will allow for much greater progress to be made in very complex, emerging fields such as systems biology. At the centre of the Research Training Group is a graduate programme with the aim of educating PhD students in all fields necessary for understanding complex biological systems. This programme builds upon the highly successful bachelor/master/diploma programmes in bioinformatics that have been offered in Munich since 2000 and in Moscow since 2002. The advantage of the Research Training Group PhD programme is that it forms a network of graduate students addressing a common set of problems with a diverse array of interdisciplinary tools. This is ensured with the central research focus via the implementation and the innovative concept of the Research Training Group enabling and requiring both competitive individual PhD projects as well as cooperation via sharing of data and models. Students will receive both theoretical and experimental training and will have the opportunity to learn specialised skills from participating labs at all three universities. Thus, their training will go well beyond of what is normally provided within a single academic faculty, department or group. The output will be a new generation of scientists who are able to explore the vast amounts of genetic, genomic and proteomic data that are being produced and integrate them into a new understanding of how cellular processes are regulated.