Studies on Clarification of Pathological Conditions of Osteoporosis in the Ora

牙种植体的应用对于改善因牙齿缺失而导致的咀嚼功能障碍和化妆品受损具有重要意义。颌骨种植治疗的成功和这种状况的始终如一的维持。种植体植入后的临床病程似乎也受到种植体所在颌骨的结构和成分的影响。近年来，一些研究人员对骨质疏松的个体进行了研究，指出颌骨中的骨小梁减少，牙周病和缺牙的发生率增加。提示在种植牙的应用中，有必要考虑骨质疏松引起的病理性骨改变。在本研究中，我们对雌性大鼠进行了卵巢切除，以建立绝经后模型，并从形态上评价了病理性骨变化对种植体周围骨反应的影响。在颌骨数量减少的个体中，他们的种植体没有得到足够的支撑，这可能是由于与种植体接触的周围骨组织减少，尤其是松质骨组织减少，以及周围骨小梁稀少所致。考虑到本研究的条件，我们应该认识到胫骨和颌骨之间可能存在的病理状况的差异，因此在制定骨质疏松症患者种植体应用指南之前，有必要对口腔颌面部骨质疏松的病理状况进行进一步的研究。

The application of dental implant is significantly useful for the improvement masticatory dysfunction and impaired cosmetics due to missing teeth. The success implant therapy on the jaw bone and the consistent maintenance of this condition. It seems that the clinical course following the application of dental implant is also affected by the structure and components of the jaw bone in which the prosthesis is implanted. Recently several researchers have studied the individuals with osteoporosis and pointed out the decrease of trabecular bone in the jaw bone and the increase in the incidence of periodontal disease and missing tooth. These findings suggested the necessity of consider the pathological bone changes due to osteoporosis in the application of dental implant. In the present study, we conducted ovariectomy on female rats to prepare postmenopausal models and morphologically evaluated the effects of pathological bone changes on the bone reactions around the dental implants. In the individuals who showed the reduced quantity of jaw bone, their dental implants were not sufficiently supported probably because of the decrease in the tissues of circumferential bones, especially cancellous banes, in contact with the dental implant and the scantiness of circumferential bone trabeculae.In the present study, we used the proximal part of the tibia as a pathological model of osteoporosis. Considering the conditions of the present study, we should recognize the possible difference in pathological conditions between tibia and jaw bones.Therefore further studies on the pathological conditions of osteoporosis in the oral and maxillofacial region are necessary before the establishment of the guidelines for the application of dental implant in the individuals with osteoporosis.