Wobble Genomics: Unlocking the world of genes
Wobble Genomics: Unlocking the world of genes
批准号:
10000729
负责人:
金额:
$37.78万
依托单位:
依托单位国家:
英国
项目类别:
Study
财政年份:
2021
资助国家:
英国
项目状态:
已结题
起止时间:
2021 至 --
中文摘要
想象一下,如果我们能找到每一个基因,我们能做什么。我们可以培育出抗病的农作物,开发更好的癌症治疗方法,或者在疾病变得无法治愈之前对其进行诊断。摇摆基因组学正在努力使这成为现实。基因是所有生命的基础。你身体里的每个细胞都在以RNA的形式持续表达基因。这些RNA是为生物功能提供方向的信号。如果我们能理解这些信号,我们就能破译生命的密码。我们检测这些信号的最先进方法是通过一种名为RNA测序的技术。虽然这项技术有可能给广泛的生物学带来革命性的变化,但它目前受到一种基本生物学现象的限制。细胞产生的大部分核糖核酸是所有细胞共有的,因此没有信息量。这意味着我们通过RNA测序获得的大部分数据基本上都是噪声。我们的Level-Up技术通过使找到重要的RNA变得更容易,而我们的TAMA软件提供了对基因功能的更深入的了解,从而解决了这个问题。发现和了解这些RNA/基因将有助于广泛的生物技术,包括药物开发、诊断、基因编辑、农业和保护工作。摇摆基因组学将帮助迎来RNA时代,并为下一代生物技术提供基础。
英文摘要
Imagine what we could do if we could find every gene. We could breed crops resistant to disease, develop better treatments for cancer, or diagnose illnesses before they become untreatable. Wobble Genomics is working to make this a reality.Genes are the basis of all life. Every cell in your body is constantly expressing genes in the form of RNA. These RNA are signals which provide directions for biological functions. If we could understand these signals, we could decipher the code of life. Our most advanced means of detecting these signals is through a technology called RNA sequencing.While this technology has the potential to revolutionize a wide range of biology, it is currently limited by a basic biological phenomenon. Most of the RNA produced by a cell are common to all cells and are thus uninformative. This means that most of the data we attain through RNA sequencing is essentially noise.Our Level-Up technology solves this problem by making it easier to find important RNA while our TAMA software provides greater insight into gene functions. Finding and understanding these RNA/genes will benefit a wide range of biotechnology including drug development, diagnostics, gene editing, agriculture, and conservation efforts.Wobble Genomics will help usher in the age of RNA and provide a foundation for the next generation of biotechnology.
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国内基金
海外基金
联合基因组重测序和10× Genomics scRNA-Seq解析乌骨鸡胸肌黑色素转运的分子机制
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批准号:32072711
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项目类别:面上项目
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资助金额:58.0万元
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批准年份:2020
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负责人:郭松长
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依托单位:
Journal of Genetics and Genomics
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批准号:31224803
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项目类别:专项基金项目
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资助金额:24.0万元
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批准年份:2012
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负责人:于昕
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依托单位: