Probing High-Throughput Drug Molecule Crystallisation Methods via Electron Diffraction

许多现代药物是以片剂或胶囊的形式服用的，其中负责提供医疗益处的药物分子通常以小晶体的形式存在。这些分子晶体的形式，基于药物分子在晶体中的排列方式，可以对药物被患者吸收的速度产生重大影响，从而开始治疗他们的疾病。因此，在设计和开发新药时，了解分子在晶体中的排列方式是非常重要的。通过将最先进的Indicatrix晶体学高通量机器人结晶技术与Eldico Science的尖端电子衍射技术相结合，该项目旨在开发新的、快速和经济高效的方法来发现和分析新的和现有的药物分子的晶体形式。由此产生的平台技术将加快未来药物的开发，减少药物从实验室到医院的进展时间，从而最大化患者的利益。

Many modern medicines are taken either as a tablet or capsule, in which the drug molecules responsible for giving the medical benefit are often present as small crystals. The form which these molecular crystals take, based on how the drug molecules are arranged within the crystal, can have a significant impact on how quickly the drug is absorbed by the patient and thus gets to work treating their disease. So understanding how the molecules are arranged in the crystal is very important when designing and developing a new drug. By combining the state-of-the-art high through-put robotic crystallisation technology of Indicatrix Crystallography with cutting-edge electron diffraction technology of Eldico Scientific, this project aims to develop new, rapid and cost-efficient methods to discover and analysis the crystal forms of both new and existing drug molecules. The resulting platform technology will speed the development of the drugs of the future, decreasing the time taken to progress a drug from the laboratory to the hospital, thus maximising patient benefits.