Characterising BiologIC’s disruptive bioprocessing platform for synthetic biology including therapies, foods and diagnostics

人类面临三大巨大挑战：到2050年养活98亿人，减缓气候变化，消除包括人畜共患病流行病在内的疾病对人类生存的威胁。BiologIC公司正在开发世界上第一台生物计算机。BiologIC的目标是建立一个世界领先的英国生物计算产业，以释放合成生物学的全部潜力。BiologIC的技术旨在彻底改变生物处理，就像集成电路彻底改变信息处理一样。其结果将是在检测和减轻疾病、食品生产、开发新的生物燃料和生物材料以及DNA数据处理方面的范式转变。BiologIC突破性的数字硬件架构使用多材料3d打印将流体、电子、热、光学和气动电路制造成集成的生物处理器。这些生物处理器组装在生物计算设备中，增加了合成生物学的处理能力。该设备还结合了一个密集的生物传感器网络，如pH值和溶解氧，生成丰富的数据，以驱动自适应工作流程。正在开发产品，以推进在研究、诊断、治疗（如新疫苗、培养肉和生物燃料）方面的应用，并旨在为下一代大规模合成生物学提供动力。工作范围是将生物过程的性能与适当的分析物和指标相结合，以帮助监测在规定的操作条件下生产或检测的生物质量。建立过程和产品之间的关系需要定制的、非琐碎的分析，可能使用不同的和互补的测量。该分析将调查和验证BiologIC架构的可行性，并支持高通量生物处理系统的开发。从长远来看，这项工作有望为持续监测产品质量的计划奠定基础，从而开发下一代3d打印设备。

Humanity faces three enormous challenges: feeding 9.8 billion people by 2050, mitigating climate change and eliminating the existential threat of diseases including zoonotic pandemics.BiologIC is developing the world's first biocomputer. BiologIC's ambition is to build a world leading UK biocomputing industry to unleash the full potential of synthetic biology. BiologIC's technology aims to revolutionise bioprocessing in the way the integrated circuit revolutionised information processing. The outcome would be a paradigm shift in the detection and mitigation of diseases, the production of foods, the development of new biofuels and biomaterials and DNA data processing.BiologIC's breakthrough digital hardware architectures use multi-material 3D-printing to fabricate fluidics, electronics, thermals, optics and pneumatic circuits into integrated bioprocessors. These bioprocessors are assembled within biocomputing devices that increase the processing power of synthetic biology. The devices also incorporate a dense network of biosensors, such as pH and dissolved oxygen, generating rich data to drive adaptive workflows.Products are being developed to advance applications in research, diagnostics, therapies such as new vaccines, cultured meat and biofuels and are designed to power the next generation of synthetic biology at scale.The scope of work is to couple the performance of the bioprocesses with appropriate analytes and metrics to help monitor the quality of the biologic produced or detected under defined operating conditions. Establishing relations between the process and product would require bespoke, non-trivial analysis, possibly using different and complementary measurements.The analysis will investigate and validate the feasibility of BiologIC's architectures and support development of high-throughput bioprocessing systems. In the longer term, this work is expected to underpin a scheme for continuous monitoring of product quality, leading to next generations of our 3D-printed devices.